Proteins & Peptides

Purified proteins and peptides are important tools in elucidating the function and biological roles of these essential cellular components. Native and recombinant proteins can be used in a wide range of applications, including:

Structural biology
Protein-protein interactions
Mass spectrometry
Positive controls in ELISA and other antibody assays
Functional studies, such as Surface Plasmon Resonance (SPR)

Biologics development
Enzyme kinetics
Screening inhibitors
Antibody production
Epitope mapping

We offer over 9,000 high quality native and recombinant proteins and peptides from mammalian, insect, yeast, and bacterial expression systems, including tools for investigating transmembrane proteins.

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Protein and peptide formats

Recombinants

Native

Biologically active

Full length

Extracellular domains

Membrane proteins

We offer a variety of formats of transmembrane proteins, which are historically challenging to manipulate due to their tendency to aggregate and the necessity to maintain their native 3D structure. All of the systems below allow the membrane protein to remain in a lipid bilayer so that they retain their natural conformation and biological activity, while being accessible for in vitro experiments, drug discovery and biologics development. Learn more about transmembrane proteins here.

Synthetic Nanodiscs

Nanodiscs hold transmembrane proteins within a phospholipid bilayer, stabilized by a polymer belt. This mimics the natural lipid environment, allowing membrane proteins to maintain native conformation & activity.

Virus-like Particles (VLPs)

VLPs self-assemble from structural viral proteins, but lack a viral genome and are non-infectious. VLPs incorporate membrane proteins into their membranes as they bud from the cell.

Exosome Products

Exosomes are naturally secreted by cells and endogenously contain a variety of protein and RNA molecules. Overexpressed proteins localized to the cell membrane can be secreted in exosomes, collected & purified.

Membrane Nanoparticles (MNPs)

MNPs comprise a synthetic nanoparticle core coated with a layer of natural cell membrane. Cell membrane containing the target protein is fragmented and isolated prior to nanoparticle coating.

Comparison of protein expression systems

Our recombinant proteins are expressed in several different host systems. Selecting the right expression system for your application can be critical to the success of your experiment. The table below outlines the features of each of our expression systems, from bacteria to human cells.

	Human (HEK293)	Mammalian (CHO)	Insect (Sf9)	Yeast	E. coli
Post-translational modifications	Full	Nearly full	Partial	Partial	None
Protein folding	Optimal	Excellent	Good	Partial	Poor
Quantity of protein produced	Low	Higher than human	Moderate	Moderate	High
Scalability	Poor	Moderate	Excellent	Excellent	Excellent
Bioactivity	Native	High	Partial	Partial	Poor

Tagged recombinant proteins

Avi-tagged proteins

Biotinylated proteins

FC-tagg proteins

Flag-tagged proteins

GST tagged proteins

His tagged proteins

Myc-tagged proteins

T7-tagged proteins

Resources

Purified proteins and peptides are essential for studying cellular functions. We offer high-quality proteins and peptides from mammalian, insect, yeast, and bacterial expression systems, including tools for transmembrane protein research.